STS (Sequence-Tagged Sites) based kit for rapid and accurate detection of Y chromosome microdeletions.
AZFScreen kit is developed for detection of Y chromosome microdeletions – a frequent genetic cause of infertility in men. Our kit includes 16 markers (13 STS markers, 2 SD (Segmental Duplication) and 1 STR (Short Tandem Repeat)). Primer designing followed European Molecular Genetics Quality Network guidelines. Male infertility is a critical health problem that affects 8-12% of reproductive-aged couples worldwide. Male infertility contributes to about 20-30% of these cases, out of which 5-10% are caused by Y chromosome microdeletions. AZFScreen kit performance has been validated with extensive testing using Applied Biosystems™ 3500/3500xL and 3130/3130xl platforms for detection and analysis on more than 100 samples.
For Research Use only. Not for use in diagnostic procedures
Certificate of Analysis
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Why is this test important?
Infertility is a critical health problem that affects 8-12% of reproductive-aged couples worldwide. Male infertility contributes to about 20-30% of these cases, out of which 5-10% of these are caused by Y-chromosome microdeletions.
Science behind it
Microdeletions in the long arm of the Y chromosome can cause spermatogenic failure. The critical region for spermatogenesis is the azoospermia factor (AZF), the deletion of which causes azoospermia. Four loci, AZFa, AZFb, AZFc and AZFd required for normal spermatogenesis, are in the AZF regions. Diagnosing the major cause of azoospermia is an initial and important step in the treatment process for infertile men.